| CAS Number: | 159858-22-7 |
| Product Name: | Fmoc-Val-Cit-PAB (9H-fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate 9H-fluoren-9-ylmethyl N-[(2S)-1-[[(2S)-5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate |
| Formula: | C33H39N5O6 |
| MW: | 601.7 |
| Appearance: | White to off-white powder |
| Purity: | not less than 98% |
| Storage Conditions: | Keep in a dark and cool dry place(-5 to 8 °C) in closed vessels. |
| Shipping Conditions: | Ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during standard shipping and time spent in Customs. |
| MOQ: | 5 grams,10 grams, 25 gram,s or more |
| Package | In alu foil bag or in Brown vial or HDPE plastic bottle |
| Production Capacity: | Kilograms Scale, bulk order |
| Availability: | More than 100 grams in stock |
| Report: | HNMR and CoA |
Known Application
Fmoc-Val-Cit-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADC). The Val-Cit is specifically cleaved by cathepsin B. As this enzyme is only present in the lysosome the ADC payload will be release only in the cell. The Fmoc is a Protecting group that can protect the N-terminal of the peptide chain, it can be deprotected under basic condition to obtain the free amine which can be used for further conjugations.
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