Fmoc-Val-Cit-OH is a peptide compound containing a Fmoc-Protecting group and two amino acids residues Valine(Val) and Citrulline(Cit). Val-Cit is a cleavable ADC linker used in antibody drug conjugate. The Val-Cit linker was designed to be cleaved by cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. The Fmoc is a Protecting group that can protect the N-terminal of the peptide chain, it can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. Reagent only for research!

There are standard samples stock with purity not less than 95%!